名古屋大学布施研究室発足前の原著論文（～2019.11.）
2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 ～2008
70) Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity,
S. Fuse, K. Suzuki, T. Kuchimaru, T. Kadonosono, H. Ueda, S. Sato, S. Kizaka-Kondo, H. Nakamura,*
Bioorg. Med. Chem. 28, 115207 (2020).
69) The design, synthesis, and evaluation of azo D-π-A dyes as photothermal agents,
S. Fuse,* T. Oishi, K. Matsumura, Y. Hayashi, S. Kawauchi, H. Nakamura*
Org. Biomol. Chem. 18, (1), 93-101 (2020).
68) Peptide chain elongation using unprotected amino acids in a micro-flow reactor,
S. Fuse,* K. Masuda, Y. Otake, H. Nakamura
Chem. Eur. J. 25, (66), 15091-15097 (2019).
Inside Cover Picture
Synfacts 01/2020にてハイライト
67) Donor–acceptor polymers containing thiazole-fused benzothiadiazole acceptor units for organic solar cells,
T. Nakamura, Y. Ishikura, N. Arakawa, M. Hori, M. Sato, M. Endo, H. Masui, S. Fuse, T. Takahashi, Y. Murata, R. Murdey, A. Wakamiya,*
RSC Adv. (9), 7107-7114 (2019).
66) Elucidating the mode of action for thiophene-based organic D-π-A sensitizers for use in photodynamic therapy,
S. Fuse,* M. Takizawa, S. Sato, S. Okazaki, H. Nakamura,*
Bioorg. Med. Chem. 27, (2), 315-321 (2019).
65) Synthesis of 3-hydroxy-4-substituted-picolinonitriles from
4-propargylaminoisoxazoles via stepwise and one-pot isoxazolopyridine formation/N-O bond cleavage sequence,
S. Fukuhara, S. Yugandar, S. Fuse, H. Nakamura,*
ACS Omega 3, (12), 16472-16476 (2018).
64) The design, synthesis, and evaluation of organic dithienopyrrole-based D-π-A dyes for use as sensitizers in photodynamic therapy,
S. Fuse,* K. Matsumura, M. Takizawa, S. Sato, H. Nakamura,*
Bioorg. Med. Chem. Lett. 28, (18), 3099-3104 (2018).
63) Rapid and mild synthesis of amino acid N-carboxy anhydrides using basic-to-acidic flash switching in a micro-flow reactor,
Y. Otake, H. Nakamura, S. Fuse,*
Angew. Chem. Int. Ed. 57, (35), 11389-11393 (2018).
化学工業日報掲載（H30/8/6）
Synfacts 12/2018にてハイライト
62) Compact test set for sensitivity evaluation of photoacoustic contrast agent,
X. Zeng,* Y. Mizuno, K. Nakamura, S. Fuse, H. Nakamura,
Acoust. Sci. Technol. 39, (3), 259-262 (2018).
61) Gold(I)-catalyzed intramolecular SEAr reaction: Efficient synthesis of isoxazole-containing fused heterocycles,
T. Morita, S. Fukuhara, S. Fuse, H. Nakamura,*
Org. Lett. 20, (2), 433-436 (2018).
Synfacts 04/2018にてハイライト
60) D–π–A dyes containing novel hydantoin anchoring groups for dye-sensitized solar cells,
H. Masui, M. M. Maitani, S. Fuse, A. Yamamura, Y. Ogomi, S. Hayase, T. Kaiho, H. Tanaka, Y. Wada, T. Takahashi,*
Asian J. Org. Chem. 7, (2), 458-464 (2018).
59) Synthesis of pyrazolofuropyrazine via one-pot SNAr reaction/intramolecular C-H direct arylation,
S. Fuse,* M. Inaba, S. Sato, M. Joshi, H. Nakamura,*
Synthesis 50, (7), 1493-1498 (2018).
58) Photodynamic therapy using using a cytotoxic photosensitizer porphyrus envelope that targets the cell membrane
M. Inai,* N. Honda, H. Hazama, S. Akter, S. Fuse, H. Nakamura, T. Nishikawa, Y. Kaneda, K. Awazu,
Photodiag. Photodyn. Ther. 20, 238-245 (2017).
57) Thiophene-based, organic D-π-A dyes as potent sensitizers for photodynamic therapy,
S. Fuse,* M. Takizawa, K. Matsumura, S. Sato, S. Okazaki, H. Nakamura,*
Eur. J. Org. Chem. (34), 5170-5177 (2017).
56) Solution-phase automated synthesis of α-amino aldehyde as a versatile intermediate,
H. Masui, S. Yosugi, S. Fuse, T. Takahashi,*
Beilstein J. Org. Chem. 13, 106-110 (2017).
55) A rapid and clean synthetic approach to cyclic peptides via micro-flow peptide chain elongation and photochemical cyclization: Synthesis of a cyclic RGD peptide,
Y. Mifune, H. Nakamura, S. Fuse,*
Org. Biomol. Chem. 14, (47), 11244-11249 (2016).
54) Development of 1-aryl-3-furanyl/thienyl-imidazopyridine templates for inhibitors against hypoxia inducible factor (HIF)-1 transcriptional activity,
S. Fuse, T. Ohuchi, Y. Asawa, S. Sato, H. Nakamura,*
Bioorg. Med. Chem. Lett. 26, (24), 5887-5890 (2016).
53) Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation,
S. Fuse,* Y. Mifune, H. Nakamura, H. Tanaka,
Nat. Commun. 7, 13491, doi: 10.1038/ncomms13491, (2016).
日経産業新聞掲載（H28/12/2）
科学新聞掲載（H28/12/9）
ScienceNewlineにてハイライト
PHYS ORGにてハイライト
Follow Newsにてハイライト
TECHNOLOGY TODAYにてハイライト
New-Medical.netにてハイライト
52) The design, synthesis, and evaluation of 1,5,7-trisubstituted-3-pyridyl-xanthones for use as insecticides starting from pyripyropene A,
S. Fuse,* K. Matsumura, K. Johmoto, H. Uekusa, H. Tanaka, T. Hirose, T. Sunazuka, S. Ōmura, T. Takahashi,
Chem. Eur. J. 22, (51), 18450-18455 (2016).
Hot Paper
51) Generation of 4-isoxazolyl anion species: facile access to multi-functionalized isoxazoles,
T. Morita, S. Fuse,* H. Nakamura,*
Angew. Chem. Int. Ed. 55, (43), 13580-13584 (2016).
Synfacts 12/2016にてハイライト
50) The synthesis of trans-flavan-3-ol gallates by regioselective oxidative etherification and their cytotoxicity mediated by 67LR,
N. Shiraishi, M. Kumazoe, S. Fuse, H. Tachibana, H. Tanaka,*
Chem. Eur. J. 22, (37), 13050-13053 (2016).
49) 6-Azido-6-deoxy-L-idose as a hetero-bifunctional spacer for the synthesis of azido-containing chemical probes,
H. Hamagami, M. Kumazoe, Y. Yamaguchi, S. Fuse, H. Tachibana, H. Tanaka,*
Chem. Eur. J. 22, (36), 12884-12890 (2016).
48) Synthesis of asymmetrically terminal bifunctionalized alkanes by sequential Suzuki-Miyaura coupling using B-thexyl boracyclanes,
R. Suzuki, S. Fuse, H. Tanaka,*
Eur. J. Org. Chem. (21), 3478-3481 (2016).
47) The α-glycosidation of partially unprotected N-acetyl and N-glycolyl sialyl donors in the absence of a nitrile solvent effect,
T. Aoyagi, S. Ohira, S. Fuse, J. Uzawa, Y. Yamaguchi, H. Tanaka,*
Chem. Eur. J. 22, (20), 6968-6973 (2016).
46) Synthesis of D-A’-π-A dyes via one-pot three-component Suzuki-Miyaura coupling and an evaluation of the photovoltaic properties for use in DSSCs,
S. Irie, S. Fuse,* M. M. Maitani, Y. Wada, Y. Ogomi, S. Hayase, T. Kaiho, H. Masui, H. Tanaka, T. Takahashi,
Chem. Eur. J. 22, (7), 2507-2514 (2016).
45) Synthesis and evaluation of thiophene-based organic dyes containing a rigid and non-planar donor with secondary electron Donors for use in dye-sensitized solar cells,
S. Fuse,* R. Takahashi, M. M. Maitani, Y. Wada, T. Kaiho, H. Tanaka, T. Takahashi,
Eur. J. Org. Chem. (3), 508-517 (2016).
44) A facile preparation of α-aryl carboxylic acid via one-flow Arndt-Eistert synthesis,
S. Fuse,* Y. Otake, Y. Mifune, H. Tanaka,
Aust. J. Chem. (invited) 68, (11), 1657-1661 (2015).
43) Directing group/protecting group-free synthesis of tetraaryl-substituted pyrazoles via four direct arylations on an unsubstituted pyrazole scaffold,
S. Fuse,* T. Morita, K. Johmoto, H. Uekusa, H. Tanaka,
Chem. Eur. J. 21, (41), 14370-14375 (2015).
Hot Paper
Inside Cover Picture
42) Palladium-catalyzed double carbonylation-based diversity-oriented synthesis of 3,4-dihydroisoquinoline-1 -carboxamides,
H. Masui, N. Ishizawa, S. Fuse, T. Takahashi,*
Tetrahedron 71, (37), 6354-6360 (2015).
ChemInform 46, (44), (2015)にてハイライト
41) Regio-selective, one-pot, three-component synthesis of 1,3,4- and 1,3,5-triaryl pyrazoles from 1- and 2-aryl-1-alkenyl sulfones,
S. Fuse,* H. Sugiyama, D. Kobayashi, Y. Iijima, K. Matsumura, H. Tanaka, T. Takahashi,
Eur. J. Org. Chem. (21), 4756-4764 (2015).
40) Sequential SNAr reaction/Suzuki-Miyaura coupling/C-H direct arylations approach for the rapid synthesis of tetraaryl-substituted pyrazoles,
T. Morita, D. Kobayashi, K. Matsumura, K. Johmoto, H. Uekusa, S. Fuse,* T. Takahashi,
Chem. Asian J. 10, (8), 1626-1630 (2015).
Cover Picture
2015/7-8 Most-accessed Articles
ChemInform 46, (52), (2015)にてハイライト
Wiley Hottest Articles in Organic Chemistryに選定
39) Asymmetric total synthesis of ent-pyripyropene A,
S. Fuse,* A. Ikebe, K. Oosumi, T. Karasawa, K. Matsumura, M. Izumikawa, K. Johmoto, H. Uekusa, K. Shin-ya, T. Doi, T. Takahashi,*
Chem. Eur. J. 21, (26), 9454-9460, (2015).
38) Rapid synthesis of thiophene-based, organic dyes for DSSCs via a one-pot, four-component coupling approach,
K. Matsumura, S. Yoshizaki, M. M. Maitani, Y. Wada, Y. Ogomi, S. Hayase, T. Kaiho, S. Fuse,* H. Tanaka, T. Takahashi,
Chem. Eur. J. 21, (27) 9742-9747, (2015).
37) Facile, one-step synthesis of 5-substituted thieno[3,4-c]pyrrole-4,6-dione by palladium-catalyzed carbonylative amidation,
S. Fuse,* R. Takahashi, T. Takahashi,
Eur. J. Org. Chem. (16), 3430-3434, (2015).
ChemInform 46, (39), (2015)にてハイライト
36) Synthesis of EDOT-containing organic dyes via one-pot, four-component Suzuki-Miyaura coupling procedure and their evaluation of photovoltaic properties,
S. Fuse,* Y. Asai, S. Sugiyama, K. Matsumura, M. M. Maitani, Y. Wada, Y. Ogomi, S. Hayase, T. Kaiho, T. Takahashi,*
Tetrahedron 70, (45), 8690-8695, (2014).
35) Rapid library synthesis of amphiphiles based on a dioxinone scaffold and identification of nonlamellar liquid crystals,
S. Fuse,* K. Nakamura, Y. Mifune, H. Marubayashi, I. Hijikuro, S. Nojima, H. Tanaka, T. Takahashi,
Synlett,25, (19), 2806-2813, (2014).
34) Elucidation of the structure-property relationship of p-type organic semiconductors through rapid library construction via a one-pot, Suzuki-Miyaura coupling reaction,
S. Fuse,* K. Matsumura, A. Wakamiya, H. Masui, H. Tanaka, S. Yoshikawa,
T. Takahashi,
ACS Comb. Sci. 16, (9), 494-499, (2014).
2014/8-9 Most-read Articles
33) Total synthesis and stereochemistry revision of mannopeptimycin aglycone,
S. Fuse,* H. Koinuma, A. Kimbara, M. Izumikawa, Y. Mifune, H. He, K. Shin-ya, T. Takahashi, T. Doi,*
J. Am. Chem. Soc. 136, (34), 12011-12017, (2014).
32) Development of dual targeting inhibitors against aggregations of amyloid-β and tau protein,
S. Fuse,* K. Matsumura, Y. Fujita, H. Sugimoto, T. Takahashi,
Eur. J. Med. Chem. 85, 228-234, (2014).
31) Synthesis of N-allyloxycarbonyl 3,5-dihydroxyphenylglycine via photochemical Wolff rearrangement/nucleophilic addition sequence in a micro-flow reactor,
Y. Mifune, S. Fuse,* H. Tanaka
J. Flow. Chem. (Asia Special Issue, invited), 4, (4), 173-179, (2014).
30) Rapid and structurally diverse synthesis of multi-substituted β-keto
amide derivatives based on a dioxinone scaffold,
S. Fuse,* H. Yoshida, K. Oosumi, T. Takahashi,
Eur. J. Org. Chem. (22), 4854-4860, (2014).
29) Elucidating the structure-property relationship of donor-p-acceptor dyes for DSSCs through rapid library synthesis via a one-pot procedure,
S. Fuse,* S. Sugiyama, M. M. Maitani, Y. Wada, Y. Ogomi, S. Hayase,
R. Katoh, T. Kaiho, T. Takahashi,
Chem. Eur. J. (Special Issue Young Chemist, invited), 20, (34), 10685-10694, (2014).
28) An efficient amide bond formation through the rapid and strong activation of carboxylic acids in a micro-flow reactor,
S. Fuse,* Y. Mifune, T. Takahashi,
Angew. Chem. Int. Ed. 53, (3), 851-855, (2014).
化学工業日報掲載（H26/1/24）
日刊工業新聞掲載（H26/1/28）
科学新聞掲載（H26/2/7）
J. Flow Chem. 4, (2), (2014)にてハイライト
ChemInform 45, (30), (2014)にてハイライト
ファルマシア, 50, 103, (2014), エディターズ・アイにてハイライト
日刊工業新聞ビジネスラインにてハイライト
Wako Organic Square 53, (2015)ペプチド合成の最近の進歩にてハイライト
27) Micro-flow synthesis and structural analysis of sterically crowded, diimine ligands with five aryl rings,
S. Fuse,* N. Tanabe, A. Tannna, Y. Konishi, T. Takahashi,
Beilstein J. Org. Chem. 9, 2336-2343, (2013).
26) Design and synthesis of 2-phenyl-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-ones as potential anticancer agents starting from cytotoxic spiromamakone A,
S. Fuse, K. Inaba, M. Takagi, M. Tanaka, T. Hirokawa, K. Johmoto, H. Uekusa, K. Shin-ya, T. Takahashi,* T. Doi,*
Eur. J. Med. Chem. 66, 180-184, (2013).
25) A sequential coupling approach to the synthesis of nickel(II) complexes with N-aryl-2-amino phenolates,
S. Fuse, H. Tago, M. M. Maitani, Y. Wada, T. Takahashi,*
ACS Comb. Sci. 14, (10), 545-550, (2012).
24) A one-pot, three-component coupling approach to the synthesis of α-iminocarboxamides,
H. Masui, S. Fuse, T. Takahashi,*
Org. Lett. 14, (16), 4090-4093, (2012).
ChemInform 43, (51), (2012)にてハイライト
23) Continuous-flow synthesis of activated vitamin D3 and its analogues,
S. Fuse, Y. Mifune, N. Tanabe, T. Takahashi,*
Org. Biomol. Chem. 10, (27), 5205-5211, (2012).
Cover Picture
22) An iterative approach to the synthesis of thiophene-based organic dyes,
S. Fuse, H. Yoshida, T. Takahashi,*
Tetrahedron Lett. 53, (26), 3288-3291, (2012).
21) Combinatorial synthesis and evaluation of α-iminocarboxamide-nickel (II) catalysts for the copolymerization of ethylene and a polar monomer,
S. Fuse, H. Masui, A. Tannna, F. Shimizu, T. Takahashi,*
ACS Comb. Sci. 14, (1), 17-24, (2012).
2012/1 Most-read Articles
20) Continuous in situ generation and reaction of phosgene in a microflow system,
S. Fuse, N. Tanabe, T. Takahashi,*
Chem. Commun. (47), 12661-12663, (2011).
J. Flow Chem. 2, (1), (2012)にてハイライト
19) JBIR-56 and JBIR-57, 2(1H)-pyrazinones from a marine sponge-derived Streptomyces sp. SpD081030SC-03,
K. Motohashi, K. Inaba, S. Fuse, T. Doi, M. Izumikawa, S. T. Khan, M. Takagi,* T. Takahashi, K. Shin-ya,*
J. Nat. Prod. 74, (7), 1630-1635, (2011).
2011/7 Most-read Articles
18) Three-component coupling approach toward the synthesis of a resorcylic acid lactone framework,
S. Sugiyama, S. Fuse, T. Takahashi,*
Tetrahedron, 67, (35), 6654-6658, (2011).
17) Ribosomal synthesis of backbone-macrocyclic peptides containing γ-amino acids,
Y. Ohshiro, E. Nakajima, Y. Goto, S. Fuse, T. Takahashi, T. Doi, H. Suga,*
ChemBioChem,12, (8), 1183-1187, (2011).
Cover Picture
2011/5 Most-accessed Articles
16) Total synthesis of spiruchostatin B aided by an automated synthesizer,
S. Fuse, K. Okada, Y. Iijima, A. Munakata, K. Machida, T. Takahashi,*
M. Takagi, K. Shin-ya, T. Doi,*
Org. Biomol. Chem. 9, (3), 3825-3833, (2011).
15) Anti-influenza virus compound from Streptomyces sp. RI18,
M. Takagi,* K. Motohashi, A. Nagai, M. Izumikawa, M. Tanaka, S. Fuse, T.
Doi, K. Iwase, A. Kawaguchi, K. Nagata, T. Takahashi, K. Shin-ya,*
Org. Lett. 12, (20), 4664-4666, (2010).
14) Continuous-flow synthesis of vitamin D3,
S. Fuse, N. Tanabe, M. Yoshida, H. Yoshida, T. Doi, T. Takahashi,*
Chem. Commun. (46), 8722-8724, (2010).
Inside Cover Picture
Chem. Eng. News 2010, 88, (51), Latest Newsにてハイライト
13) Rapid assembly of resorcylic acid lactone frameworks via sequential palladium-catalyzed coupling reactions,
S. Fuse, S. Sugiyama, T. Takahashi,*
Chem. Asian J. 5,(3), 2459-2462, (2010).
ChemInform 42, (18), (2011)にてハイライト
12) Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity,
H. Tanaka,* Y. Tanaka, M. Minoshima, S. Yamaguchi, S. Fuse, T. Doi, S. Kawauchi, H. Sugiyama T. Takahashi,*
Chem. Commun. (46), 5942-5944, (2010).
11) Functional and structural analysis of a key region of the cell wall inhibitor moenomycin,
S. Fuse, H. Tsukamoto, Y. Yuan, T-S. Wang, Y. Zang, M. Bolla, S. Walker,* P. Sliz, D. Kahne,*
ACS Chem. Biol. 5, (7), 701-711, (2010).
2010/6 Most-accessed Articles
10) Construction of the ABC ring system of taxanes via stereoselective one-pot three-component coupling and intramolecular alkylation of a protected cyanohydrin ether,
T. Serizawa, S. Miyamoto, S. Fuse, T. Doi, T. Takahashi,*
Bull. Chem. Soc. Jpn. 83, (8), 942-949, (2010).
ChemInform 41, (50), (2010)にてハイライト
9) Design, synthesis and evaluation of carbamate-modified (-)-N1-phenetylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors,
J. Takahashi, I. Hijikuro, T. Kihara, M. G. Murugesh, S. Fuse, Y. Tsumura, A. Akaike, T. Niidome, T. Takahashi, H. Sugimoto,*
Bioorg. Med. Chem. Lett. 20, (5), 1721-1723, (2010).
8) Design, synthesis and evaluation and QSAR analysis of (-)-N1-substituted
norcymserine derivatives as selective butyrylcholinesterase inhibitors,
J. Takahashi, I. Hijikuro, T. Kihara, M. G. Murugesh, S. Fuse, R. Kunimoto, Y. Tsumura, A. Akaike, T. Niidome, Y. Okuno, T. Takahashi, H. Sugimoto,*
Bioorg. Med. Chem. Lett. 20, (5), 1718-1720, (2010).
7) Development and application of a solution-phase automated synthesizer, ‘ChemKonzert,’
K. Machida,* Y. Hirose, S. Fuse, T. Sugawara, T. Takahashi,
Chem. Pharm. Bull. 58, (1), 87-93, (2010).
6) An efficient synthesis of a cyclic ether key intermediate for 9-membered masked enediyne using an automated synthesizer,
Y. Tanaka, S. Fuse, H. Tanaka, T. Doi, T. Takahashi,*
Org. Process Res. Dev. 13, (6), 1111-1121, (2009).
5) Complete characterization of the seventeen step moenomycin biosynthetic pathway,
B. Ostash, E. Doud, C. Lin, I. Ostash, D. Perlstein, S. Fuse, M. Wolpert, D. Kahne, S. Walker,*
Biochemistry 48, (37), 8830-8841, (2009).
4) Stereoselective one-pot three-component coupling approach toward the synthesis of the AC ring system of taxanes,
T. Serizawa, S. Miyamoto, Y. Numajiri, S. Fuse, T. Doi, T. Takahashi,*
Tetrahedron Lett. 50, (26), 3408-3410, (2009).
3) Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for
antibiotic design,
Y. Yuan, S. Fuse, B. Ostash, P. Sliz, D. Kahne,* S. Walker,
ACS Chem. Biol. 3, (7), 429-436, (2008).
2) A formal total synthesis of taxol aided by an automated synthesizer,
T. Doi, S. Fuse, S. Miyamoto, K. Nakai, D. Sasuga, T. Takahashi,*
Chem. Asian J. 1, (3), 370-383, (2006).
3/2006-7/2007 Most-accessed Article
ファルマシア, 43, 461, (2007)トピックスにてハイライト
1) Ti(III) catalyzed radical cyclization of 6,7-epoxygeranyl acetate,
S. Fuse, M. Hanochi, T. Doi, T. Takahashi,*
Tetrahedron Lett.45, (9), 1961-1963, (2004).